tag:blogger.com,1999:blog-7630235203124139162024-03-08T08:38:26.127-08:00Maroney BoysMcgreehttp://www.blogger.com/profile/08211025765138344385noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-763023520312413916.post-48670802105442795952018-11-24T10:02:00.002-08:002018-11-24T10:02:22.845-08:00What Is A Transgene?When considering the question what is a transgene and why is it necessary, most scientists would point to the large number of genetic research currently being used. Transgenes are an integral part of modern genetic engineering, but what exactly are they? What is their main underlying purpose and benefits, and what makes them play such a crucial role in the development of humanized mouse models and different genetic manipulation methods designed to target specific diseases?<br />
<br />
What are transgenes?<br />
Before you continue: what exactly is a transgen? The concept of a transgene has been widely understood for more than 100 years, because the rise of genetic research found its way to the 20th century. As time went on, technologies evolved, and transgenes were widely used in the late 1970s and early 80s. Transgenes are pieces of genetic material that are used to modify the genome of a particular organism. The modification of the phenotype of the organism is also possible through the use of transgenes. In order to function properly, transgenics need different key components. The promoter is a regulatory sequence that determines where and when the transgene will be activated, while the exon is in charge of the protein coding sequence and the stop sequence. A third element is the bacterial plasmid that is used to deliver these components to the host genome.<br />
<br />
Why are transgenes so important?<br />
When you ask what is a transgene, you also have to ask yourself, why were transgenes developed in the first place? Transgenic organisms have the important role to express different genes, making them vulnerable to specific disorders or conditions that researchers want to study. The valuable research gathered from the development of humanized transgenic mice, for example, has been used to develop new treatments for cancer and other equally debilitating diseases. Through advances in molecular biology, new models can be developed, allowing scientists to better study the human genome and identify conditions such as aging, diabetes, infertility and immune response.<br />
<br />
<a href="https://www.tebu-bio.com/blog/2018/05/21/gene-editing-tunr-system-to-remix-the-gene-expression-level/" target="_blank">Tebu-bio.com</a> provides gene editing service .<br />
<br />
The first transgenic organisms<br />
The first transgene to be obtained under controlled conditions by specific, genetic manipulation methods was in 1974. Staphylococcus aureus genes were then successfully introduced into e. coli. The first eukaryotic organism used in a gene transfer experiment was yeast in 1978. After yeast, the first transgenic mouse model was developed only a year later. During the first experimental experiments, DNA was transferred directly into the target cells via microinjection.<br />
<br />
Modern examples for the use of the transgene<br />
What is a transgene and how is it used today? Although there are many examples, perhaps the most significant use of transgenes in plants and food. Maize, cotton and rapeseed are just a few of the plants that have been genetically modified to maximize the yield and health of the crops. New mouse models are also regularly developed, whereby the oncomouse is a completely new genetically modified mouse species developed for the study of cancer. Given the question what is a transgene and what we should expect in the future, researchers also point to potential applications such as the xenotransplantation of organs, the development of artificial protein products and a remedy for fertility-related genetic disorders.<br />
<div>
<br /></div>
Mcgreehttp://www.blogger.com/profile/08211025765138344385noreply@blogger.com0